How to trip on weed
Marijuana is sometimes described as a hallucinogen, which may seem like Reefer Madness garbage to most tokers. However, scientists recently discovered a critical gene mutation in people who say they trip from weed, indicating that, yes, weed can act as a hallucinogen in some people.
The study, published Monday in Translational Psychiatry, was a massive joint research project with Yale University, Washington University, Indiana University, Boston University, and the University of Pennsylvania’s Schools of Medicine. The State University of New York Downstate Medical Center also contributed.
Here’s what they did. The researchers collected DNA samples from over 9,000 American subjects — roughly half of European descent and the other half of African descent. Then, they asked the subjects, “Because of your marijuana use, did you ever experience any of the following: Hearing, seeing or smelling things that weren’t really there?”
The subjects’ answers were compared to their gene sequences. Subjects who reported seeing, smelling, or hearing things “that weren’t really there” all shared one thing in common: a mutation in the CHRM3 gene, a gene responsible for a whole bunch of wild shit. And get this: the CHRM3 gene responsible for causing hallucinations likely originated in European populations, not African ones.
What does CHRM3 do, exactly? Scientists are still figuring that out, but one thing it’s responsible for is regulating our REM sleep cycles. REM, or rapid eye movement, sleep occurs when we enter the deepest stage of sleep and begin dreaming. So, just as we experience things entirely in our heads while we sleep, part of this dream world may creep into the waking world when people with the CHRM3 mutation smoke weed.
CHRM3 is also physically linked, by spatial distance, to other genes that are associated with hallucinations. In mice, we know this variant of CHRM3 tends to come with a total package of other mutant genes including versions of GABAG2, CHRNA4, and HRH3, three genes that regulate dopamine and serotonin production in our brains. And, as you probably already know, dopamine and serotonin are responsible for the trips caused by psychedelics such as LSD, psilocybin mushrooms, and DMT.
The above mentioned genes are also associated with schizophrenia, a genetically inherited, permanent mental condition marked by hallucinations. Specifically, the mutant version of CHRM3 produces an unusual protein, AChR M3, which is seen at elevated levels in schizophrenic patients. Antipsychotic drugs prescribed to schizophrenics can counteract this protein, reducing hallucinations.
Does this mean that weed can cause schizophrenia? Absolutely not. (And Harvard University has our backs on this.) Doctors believe schizophrenia is largely genetic, though some environmental factors may trigger its onset. While scientists are still debating how marijuana can contribute to schizophrenia’s symptoms, all this latest study does is show that there are some genetic similarities between people who trip on weed and people who are schizophrenic. Don’t get it twisted.
So, there you have it: Some people see, hear, or smell things that aren’t there when they’re on weed. It’s genetic; it has nothing to do with their tolerance levels, experience levels, or other drug use. And if anything, they’re getting more out of their cannabis high than folks who don’t hallucinate (just a little) from marijuana, in my totally humble, absolutely sober opinion.
So, in the name of freeing this plant, please stop shaming people who trip out when they smoke weed. They can’t help it, and elitist weedsplaining isn’t going to change that.A mutation in the CHRM3 gene, which originates in European populations, is associated with other genes that are responsible for visual and auditory hallucinations. Harry Anslinger is officially rolling over in his grave.
Bad Trip? 3 Tips on How to Overcome Getting Too High
Reading Time: 5 min 43 sec
I t’s hours later after ingesting an edible, when out of nowhere, things seem to get a little too intense . We’ve all been there – a relaxing evening suddenly turns into an experience full of anxiety and fear. Do you need to hold on for dear life, or is there a way out of this bad trip?
Luckily, there are a few ways to bring yourself out of one, but we first need to recognize what a bad trip consists of. What we experience as a bad trip, in reality, can be a domino effect from discomfort to full-blown panic.
Our mind gets caught in a vicious cycle that drives us to feel more and more fear and anxiety the higher we get. This elevated anxiety can then raise your heart rate, and possibly cause minor breathing discomfort. However, these side-effects seem more intense than they usually are, and it might be comforting to know that nobody has ever died directly from an overdose on weed .
Despite that, having a bad trip can be an incredibly uncomfortable or even terrifying experience. They can leave a lasting negative impression, making us fearful of having another similar experience.
In this article, we’ll discuss how to get out of a bad trip when you are having one, and what you can do to prevent them from happening.
#1 Prevention Is The Best Remedy
“One of the best ways to keep from getting into a bad trip is to be in a positive and calm environment.”
Before we jump into the ways to rescue yourself from a bad trip, we need to discuss the ultimate remedy – prevention. It’s much easier to keep yourself from getting too medicated than it is to get out of it.
One of the best ways to prevent yourself from getting into a bad trip is to be in a positive and calm environment. The more you have control over your surroundings, the less likely you’ll have a negative reaction.
Try to be in a place that is familiar to you, and one where you can be comfortable. Your own home, a close friend’s house, or perhaps a peaceful park are all good starts.
It’s also a good idea to be with friends that you’re comfortable with, and not with others you don’t know so well. Being alone can also be a good strategy, since sometimes just being around others can be stressful.
Another way to keep yourself from having a bad trip is to limit the amount of cannabis you consume. If you’re smoking or vaping, take a puff or two and then relax. The effects are immediate, and within 20 minutes, you’ll probably know if it’s safe to have more or not.
With edibles, it’s a different story. Since edibles sometimes take hours to have an effect , it may be difficult to initially gauge what is too much or too little. We recommend starting with a small dose (2.5mg for most), and to only have more after at least 8 hours.
We know this process may take all day to figure out your specific edible dosage, but trust us, it’s worth it. When you have your edible dose figured out, you can almost always eat the perfect amount of a THC gummy bear without going overboard.
#2 Getting Out of a Bad Trip
“The number one thing to do is try to stay calm. Of course, that’s easier said than done, but it will keep you from spiraling into a panic.”
Sometimes it just happens out of nowhere, and there’s no warning when the bad trip will strike. Maybe you had a little too much cannabis, or perhaps you’re not in the best mental state. Whatever the reason, there are a few ways to help you get back on track.
The most important thing to remember is to avoid panicking. It may feel like your heartbeat is louder than normal, or the weight of the world is crashing on top of you – but it’s not.
The number one thing to do is try to stay calm. Of course, that’s easier said than done, but it will keep you from spiraling into a panic. If you feel yourself starting to panic, try to relax your body and focus on your breathing.
Practice some light meditation by breathing in deeply and exhaling slowly. As you do this, relax each part of your body to keep yourself from being too tense.
As you breathe, remind yourself that there’s nothing actually wrong, and you’re just feeling too medicated. Remember that in some time, the feeling will pass and that it’s all temporary.
Once you partially calm yourself down, then you should try to do something else. Putting on some calm music or watching a movie can help you focus on something other than being too high.
If that doesn’t seem to help much, then a change of scenery might be in order. If you’re inside, try getting some fresh air outside, or even go on a brief walk. If you’re having an uncomfortable trip outside, then going inside might help calm you down.
Another thing to always keep in mind is hydration. We recommend drinking a lot of water, even when you’re not on a bad trip. However, during a problematic high, hydration can help keep you from spiraling out of control.
You can also have a relaxing tea or juice if you’d like, but definitely avoid alcohol. Drinking a beer or hard liquor can increase the THC levels in your blood , potentially making things worse.
If you’re around friends, they can help calm you down too. If you’re alone, then picking up the phone and getting some reassurance from someone can be a “lifesaver”.
When you have simple conversations with someone, it helps your mind stay grounded in reality. As long as they are calm and relaxed, their energy can rub off on you too.
#3 Always Have CBD On Hand
“Cannabidiol behaved as a non‐competitive negative allosteric modulator of CB1 receptors.”
CBD, also known as cannabidiol, is a non-intoxicating compound that’s often used to help reduce anxiety. Aside from helping you to relax during a bad trip, research shows that CBD can actually decrease the intensity of THC.
CBD is an allosteric modulator , which means it decreases or increases the receptor size that THC binds to. By doing so, THC is unable to bind to receptors at the same capacity, therefore making you less high. Be careful though, as you may need a very high dose of CBD to calm you down, and small doses could intensify the psychoactive effects.
If you’re worried about experiencing a bad trip from cannabis, then CBD is a must-have on hand.
Never Experience a Bad Trip Again
By following these tips, you should never experience a bad trip again. There’s nothing worse than getting too high , and it’s always best to take too little rather than too much while indulging in cannabis. If you’re ready to experience the best effects that edibles and other cannabis-based products have to offer, always keep these tips in mind.
* Disclaimer * Baked Bros NEVER recommends avoiding medical treatment if you truly think you need it. We are not doctors, and pre-existing conditions can be exacerbated by cannabis. If you feel you truly need medical attention, please seek it out. Trust your body and know your dose!Reading Time: 5 min 43 sec It’s hours later after ingesting an edible, when out of nowhere, things seem to get a little too intense. We’ve all been there – a relaxing evening suddenly turns into an experience full of anxiety and fear. Do you need to hold on for dear life, or is there a way out of this bad trip? Luckil ]]>